In the first ending song of Monster, what is the significance of the artwork and who made it?
Important: I am only halfway through Monster. Please no spoilers!
This is going to be all spoilers.
Those are pictures are from the book Obluda, Která Nemá Své Jméno or "A monster without a name" by Franz Bonaparta under the alias Emil Scherbe in the Czech language. It was first introduced in the anime at episode 37 and in chapter 71 in the manga.
Though the book itself is created by a fictional character from Monster, I believe you can actually buy a real copy of it.
See also: The nameless monster article.