Is this real or not?
This is a real image, albeit not from the manga nor anime series. Shisui's Susanoo makes its appearance in the video game Naruto Shippūden: Ultimate Ninja Storm Revolution. In fact, Shisui's Susanoo was designed by Masashi Kishimoto himself. So from that perspective, it is canon.
Why was Shisui able to activate Susanoo with just one Mangekyō Sharingan (one eye)?
Unfortunately, there is no canonical information regarding this and may have been a simple oversight from the developers of the game.
However, the answer to the question "How can Madara use Susanoo without any eyes?" may shine some light on the matter.