After reading the Manga until the current issue, it kind of feels like to me that it's building to Mikasa is going to become the Female Titan, or that Mikasa is going to inherit the Attack Titan from Eren due to the curse of Ymir.
This raised yet another question about the AoT series, can an Ackerman become a Titan shifter, seeing that this clan is one of the "special clans" that cannot be affected by Titan powers in any way, form or shape?
I would think that they can, given that the Ackerman clan was a "result of Titan Science" before or after the walls were built, explaining their enhanced abilities and skills, but still leaves the burning question, can an Ackerman become a Titan should it be inherited from elsewhere?
UPDATE
As of Chapter 112. It is revealed by Eren that the Ackerman Clan can control Titan abilties when in close proximity with a Titan Shifter, or if that Ackerman member has a relatively close bond to said Titan Shifter (e.g. Mikasa and Eren). I feel that this information is relevant to this question, and thus has been added.